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Jun 13, - Clinical depression is a medical condition that goes beyond everyday sadness. It causes profound, long-lasting symptoms and often disrupts a. Depression may sometimes be undiagnosed or misdiagnosed in some older adults because sadness is not their main symptom. They may have other, less obvious symptoms of depression or they may not be willing to talk about their feelings. Feelings of hopelessness, pessimism. Feelings of guilt, worthlessness, helplessness.